INMG

Institut NeuroMyoGène


CNRS UMR 5310 - INSERM U1217 - Université de Lyon - Université Claude Bernard Lyon 1


 
Delloye2018
Cancer Cell

Microenvironment-driven shift of a cohesion/scattering balance within tumors induces a switch towards metastasis in Neuroblastoma

Delloye-Bourgeois C, Bertin L, Thoinet K, Jarrosson L, Kindbeiter K, Buffet T, Tauszig-Delamasure S, Bozon M, Marabelle A, Combaret V, Bergeron C, Derrington E, Castellani V

The Castellani team developed an aggressive human neuroblastoma (NB) model based on the graft of NB cells at their primitive environment, the neural crest, in avian embryos. This model recapitulates both the primary tumor formation and NB cells secondary dissemination and allowed identifying two major routes of dissemination: peripheral nerves and aorta. The team described a microenvironment-induced pro-metastatic process, regulated by a cohesion signaling controlled by SEMA3C via NRP/PLXN complexes.


More information about the science of Valérie Castellani's team

 

 
Theret2017
EMBO Journal

AMPKα1-LDH pathway regulates muscle stem cell self-renewal by controlling metabolic homeostasis

Marine Theret, Linda Gsaier, Bethany Schaffer, Gaëtan Juban, Sabrina Ben Larbi, Michèle Weiss-Gayet, Laurent Bultot, Collodet Caterina, Marc Foretz, Dominique Desplanches, Pascual Sanz, Zizhao Zang, Lin Yang, Guillaume Vial, Benoit Viollet, Kei Sakamoto, Anne Brunet, Bénédicte Chazaud & Rémi Mounier

Theret et al. identify LDH as a new functional target of AMPKα1 in MuSCs, where it is a direct regulator by which the oxidative phosphorylation/aerobic glycolysis balance can be shifted to control differentiation/self-renewal.


More information about the science of Rémi Mounier and Bénédicte Chazaud's team

 

 
Angelov2017
Molecular Cell

Structure and Dynamics of a 197 bp Nucleosome in Complex with Linker Histone H1

Bednar J, Garcia-Saez I, Boopathi R, Cutter AR, Papai G, Reymer A, Syed SH, Lone IN, Tonchev O, Crucifix C, Menoni H, Papin C, Skoufias DA, Kurumizaka H, Lavery R, Hamiche A*, Hayes JJ*, Schultz P*, Angelov D*, Petosa C*, Dimitrov S*

Cryo-EM and crystal structures of the nucleosome bound to histone H1 were determined. H1 binding induces the nucleosome to adopt a more compact and rigid conformation. The H1 globular domain interacts with core DNA on the dyad and with both DNA linkers. The H1 C-terminal domain associates primarily with a single DNA linker.

Pubmed 
 
 

Research teams

INMG houses 14 research teams focusing on the physiology of the neuromuscular system, cellular and molecular neurobiology and nuclear dynamics.

News & Highlights

Jean-Louis Bessereau's team has launched the project "C.NAPSE" with the support of a prestigious ERC Advanced Grant (ERC AdG 2015) from the European Research Council.

The group of Jean-Louis Bessereau is investigating the molecular organization of chemical synapses, which are the specialized structures supporting communication between neurons in the brain and between neurons and muscles at neuromuscular junctions.

Seminars


Friday December 1st

Chantal THIBERT

Institute for Advanced Biosciences Université Grenoble Alpes. Invited by Julien Courchet

Friday Nov 10th

Michalis Averof

Institut de Génomique Fonctionnelle de Lyon (IGFL). Invited by Rémi Mounier


Job Offers

  • 2017-07-26 Julien Courchet's team is hiring a PhD STUDENT (3 years, ERC-funded) to study the molecular mechanisms involved in the local regulation of the energy metabolism in developing axon.
    More info here

Students & Training

L'INMG accueille et forme chaque année de nombreux étudiants à tous les niveaux de formation.

Facilities & Resources

Administration

Director
Pr. Laurent SCHAEFFER

Co-Director - Science policy
Pr. Jean-Louis BESSEREAU

Co-Directeur - Human resources
Dr. Guy MOUCHIROUD

Administrative hub et secretariat
Juliette CAMPANA
Laurence FOURNIER
Isabelle MEZZANO
Isabelle ROMERA
Jean-Sébastien GAILLARD

Research Teams

Students

L'INMG accueille et forme chaque année de nombreux étudiants à tous les niveaux de formation.
 
  • Internships
  • Graduate schools
    • BMIC - École Doctorale de Biologie Moléculaire, Intégrative et Cellulaire de Lyon
    • EDISS - École Doctorale Interdisciplinaire Sciences Santé
    • NSCo - Neurosciences et Cognition

logo-cnrs   logo_ucbl   logo_ucbl_hr   logo_inserm
  • Secrétariat La Doua

    Isabelle MEZZANO
    Tel.: +33 4 72 43 13 93
  • Adresse Campus La Doua

    Institut NeuroMyoGène
    CNRS UMR 5310 - INSERM U1217 - Université Claude Bernard Lyon 1
    16 rue Raphaël Dubois
    69100 Villeurbanne
    France

  • Secrétariat ENS Lyon


    Tel.: +33 4 72 72 84 16
  • Adresse Campus ENS LYON

    LBMC, UMR5239 ENS Lyon
    46 Allée d'Italie
    69007 LYON
    FRANCE

  • Secrétariat Laennec

    Juliette CAMPANA
    Tel.: +33 4 78 77 87 59
  • Adresse Campus Laënnec

    Faculté de Médecine Lyon Est – Laënnec
    Rez de chaussée Bâtiment B
    7, rue G. Paradin
    69372 LYON Cedex 08
    France