INMG

Institut NeuroMyoGène


CNRS UMR 5310 - INSERM U1217 - Université de Lyon - Université Claude Bernard Lyon 1


 
PhD Defense – Friday October 20th 14:00 - Salle des thèses Laënnec

Encéphalites à anticorps anti-NMDAR: étude clinique et mécanistique

Chloé Bost - Équipe Honnorat

Anti-NMDAR autoimmune encephalitis is characterized by the presence of IgG antibodies (Abs) directed against NMDA receptor (NMDAR). Glutamatergic synapses are the main component of excitatory transmission in the adult brain and the ionotropic glutamate receptor NMDAR has a key role in synaptic plasticity. Synaptic plasticity is defined by the synapses property to modify their transmission strength and seems to be the cellular correlate of learning and memory. In vitro and in vivo studies on anti-NMDAR Abs effects showed an altered dynamic at the membrane followed by an internalization of NMDAR. Thus, Abs seem to have a pathogenic effect, able to explain clinical symptoms. During my thesis, I wanted to deepen the understanding of this pathology on the clinical and mechanistic level. To this end, I studied the clinical and histological features of patients with an associated tumor. Results obtained allow me to establish management recommendations considering the high mortality rate in these patients and the high frequency of immature ovarian teratomas. Simultaneously, I studied the effect of anti-NMDAR Abs on synaptic transmission and plasticity in a murine model allowing chronic Abs infusion. These results obtained by electrophysiology on acute slices allowed me to demonstrate an effect of CSF Abs on synaptic plasticity but of less amplitude than the previous studies had suggested. Results also highlighted the importance of the duration to antibodies exposure. ​


More information about the science of team Honnorat

 
 
Theret2017
EMBO Journal

AMPKα1-LDH pathway regulates muscle stem cell self-renewal by controlling metabolic homeostasis

Marine Theret, Linda Gsaier, Bethany Schaffer, Gaëtan Juban, Sabrina Ben Larbi, Michèle Weiss-Gayet, Laurent Bultot, Collodet Caterina, Marc Foretz, Dominique Desplanches, Pascual Sanz, Zizhao Zang, Lin Yang, Guillaume Vial, Benoit Viollet, Kei Sakamoto, Anne Brunet, Bénédicte Chazaud & Rémi Mounier

Theret et al. identify LDH as a new functional target of AMPKα1 in MuSCs, where it is a direct regulator by which the oxidative phosphorylation/aerobic glycolysis balance can be shifted to control differentiation/self-renewal.


More information about the science of Rémi Mounier and Bénédicte Chazaud's team

 

 
Angelov2017
Molecular Cell

Structure and Dynamics of a 197 bp Nucleosome in Complex with Linker Histone H1

Bednar J, Garcia-Saez I, Boopathi R, Cutter AR, Papai G, Reymer A, Syed SH, Lone IN, Tonchev O, Crucifix C, Menoni H, Papin C, Skoufias DA, Kurumizaka H, Lavery R, Hamiche A*, Hayes JJ*, Schultz P*, Angelov D*, Petosa C*, Dimitrov S*

Cryo-EM and crystal structures of the nucleosome bound to histone H1 were determined. H1 binding induces the nucleosome to adopt a more compact and rigid conformation. The H1 globular domain interacts with core DNA on the dyad and with both DNA linkers. The H1 C-terminal domain associates primarily with a single DNA linker.

Pubmed 
 
 

Research teams

INMG houses 14 research teams focusing on the physiology of the neuromuscular system, cellular and molecular neurobiology and nuclear dynamics.

News & Highlights

Jean-Louis Bessereau's team has launched the project "C.NAPSE" with the support of a prestigious ERC Advanced Grant (ERC AdG 2015) from the European Research Council.

The group of Jean-Louis Bessereau is investigating the molecular organization of chemical synapses, which are the specialized structures supporting communication between neurons in the brain and between neurons and muscles at neuromuscular junctions.

Seminars


Thrusday October 12th

Damaris Lorenzo

Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill. Invited by Thomas Boulin

Friday Nov 10th

Michalis Averof

Institut de Génomique Fonctionnelle de Lyon (IGFL). Invited by Rémi Mounier


Job Offers

  • 2017-07-26 Julien Courchet's team is hiring a PhD STUDENT (3 years, ERC-funded) to study the molecular mechanisms involved in the local regulation of the energy metabolism in developing axon.
    More info here

Students & Training

L'INMG accueille et forme chaque année de nombreux étudiants à tous les niveaux de formation.

Facilities & Resources

Administration

Director
Pr. Laurent SCHAEFFER

Co-Director - Science policy
Pr. Jean-Louis BESSEREAU

Co-Directeur - Human resources
Dr. Guy MOUCHIROUD

Administrative hub et secretariat
Juliette CAMPANA
Laurence FOURNIER
Isabelle MEZZANO
Isabelle ROMERA
Jean-Sébastien GAILLARD

Research Teams

Students

L'INMG accueille et forme chaque année de nombreux étudiants à tous les niveaux de formation.
 
  • Internships
  • Graduate schools
    • BMIC - École Doctorale de Biologie Moléculaire, Intégrative et Cellulaire de Lyon
    • EDISS - École Doctorale Interdisciplinaire Sciences Santé
    • NSCo - Neurosciences et Cognition

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  • Secrétariat La Doua

    Isabelle MEZZANO
    Tel.: +33 4 72 43 13 93
  • Adresse Campus La Doua

    Institut NeuroMyoGène
    CNRS UMR 5310 - INSERM U1217 - Université Claude Bernard Lyon 1
    16 rue Raphaël Dubois
    69100 Villeurbanne
    France

  • Secrétariat ENS Lyon


    Tel.: +33 4 72 72 84 16
  • Adresse Campus ENS LYON

    LBMC, UMR5239 ENS Lyon
    46 Allée d'Italie
    69007 LYON
    FRANCE

  • Secrétariat Laennec

    Juliette CAMPANA
    Tel.: +33 4 78 77 87 59
  • Adresse Campus Laënnec

    Faculté de Médecine Lyon Est – Laënnec
    Rez de chaussée Bâtiment B
    7, rue G. Paradin
    69372 LYON Cedex 08
    France