Institut NeuroMyoGène

CNRS UMR 5310 - INSERM U1217 - Université de Lyon - Université Claude Bernard Lyon 1


Cytoplasmic NOTCH and membrane-derived β-catenin link cell fate choice to epithelial-mesenchymal transition during myogenesis

Daniel Sieiro, Anne C Rios, Claire E Hirst, Christophe Marcelle

How cells in the embryo coordinate epithelial plasticity with cell fate decision in a fast changing cellular environment is largely unknown. In chick embryos, skeletal muscle formation is initiated by migrating Delta1-expressing neural crest cells that trigger NOTCH signaling and myogenesis in selected epithelial somite progenitor cells, which rapidly translocate into the nascent muscle to differentiate. Here, we uncovered at the heart of this response a signaling module encompassing NOTCH, GSK-3β, SNAI1 and β-catenin.

More information about the science of team Marcelle


Research teams

INMG houses 14 research teams focusing on the physiology of the neuromuscular system, cellular and molecular neurobiology and nuclear dynamics.

News & Highlights

Julien Courchet receives ERC Starting Grant (ERC StG 2015).

Julien Courchet’s group will investigate how the regulation of glucose metabolism and mitochondria function by two kinases termed LKB1 and NUAK1 underlies neuron development and circuit formation in the cortex of the mouse.


Friday September 30th at 11:00 - Amphithéâtre CNRS

Sandrine Humbert

GIN - Inserm U1216 - University Grenoble Alpes, Grenoble, France.
Huntingtin regulates cortical development: consequences for Huntington’s disease

Friday October 7th at 14:00 - Amphithéâtre CNRS

Stéphane Vassilopoulos

Institut de Myologie, UMRS 974 UPMC-Inserm / FRE 3617 CNRS, G. H. Pitié-Salpétrière, Paris - France.
The endocytic machinery in healthy and diseased muscle

Job Offers

  • Team Boulin 2 year Post-doctoral position. (C. elegans, cellular excitability, potassium channels)
  • Team Bessereau One Post-doctoral position. (Mechanisms involved in GABAA receptor clustering at C. elegans synapses)
    more info here

Students & Training

L'INMG accueille et forme chaque année de nombreux étudiants à tous les niveaux de formation.

Facilities & Resources



Co-Director - Science policy
Pr. Jean-Louis BESSEREAU

Co-Directeur - Human resources

Administrative hub et secretariat
Juliette CAMPANA
Isabelle MEZZANO
Isabelle ROMERA
Jean-Sébastien GAILLARD

Research Teams


L'INMG accueille et forme chaque année de nombreux étudiants à tous les niveaux de formation.
  • Internships
  • Graduate schools
    • BMIC - École Doctorale de Biologie Moléculaire, Intégrative et Cellulaire de Lyon
    • EDISS - École Doctorale Interdisciplinaire Sciences Santé
    • NSCo - Neurosciences et Cognition

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  • Secrétariat La Doua

    Isabelle MEZZANO
    Tel.: +33 4 72 43 13 93
  • Adresse Campus La Doua

    Institut NeuroMyoGène
    CNRS UMR 5310 - INSERM U1217 - Université Claude Bernard Lyon 1
    16 rue Raphaël Dubois
    69100 Villeurbanne

  • Secrétariat ENS Lyon

    Tel.: +33 4
  • Adresse Campus ENS LYON

    LBMC, UMR5239 ENS Lyon
    46 Allée d'Italie
    69007 LYON

  • Secrétariat Laennec

    Juliette CAMPANA
    Tel.: +33 4 78 77 87 59
  • Adresse Campus Laënnec

    Faculté de Médecine Lyon Est – Laënnec
    Rez de chaussée Bâtiment B
    7, rue G. Paradin
    69372 LYON Cedex 08