INMG

Institut NeuroMyoGène


CNRS UMR 5310 - INSERM U1217 - Université de Lyon - Université Claude Bernard Lyon 1

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We have moved!

2018new_lab

After two years of construction, the 200 members of the NeuroMyoGène Institute moved in late December 2017 into the beautifully renovated premises of the Rockefeller School of Medicine Lyon-Est.
This operation is part of the ambitious renovation project of the Rockefeller building built in 1929 by Paul Bellemain, student of Tony Garnier, and made possible by the support of the Auvergne Rhône-Alpes region, the métropole de Lyon, the Contrat Plan Etat Région and University Claude Bernard Lyon 1.
The 14 research teams of the institute occupy 3,500 m2 of lab and office space on the third floor of the building. They benefit from state-of-the-art technical platforms for imaging, physiology and genomics.
A 500 m2 extension of the laboratory will be completed at the end of 2018, and will allow a first wave of recruitment for new teams.

 

 
UNC-120
Aging Cell

UNC-120/SRF independently controls muscle aging and lifespan in Caenorhabditis elegans.

Mergoud Dit Lamarche A, Molin L, Pierson L, Mariol MC, Bessereau JL, Gieseler K, Solari F

In this study, Mergoud et al. identify UNC-120/SRF as the first conserved transcription factor that regulates the pace of muscle aging in a cell autonomous manner, downstream of the insulin/IGF1 receptor.


More information about the science of Jean-Louis Bessereau's team

 

 
Chazaud2017
Stem Cell Reports

Coupling between Myogenesis and Angiogenesis during Skeletal Muscle Regeneration Is Stimulated by Restorative Macrophages

Latroche C, Weiss-Gayet M, Muller L, Gitiaux C, Leblanc P, Liot S, Ben-Larbi S, Abou-Khalil R, Verger N, Bardot P, Magnan M, Chrétien F, Mounier R, Germain S, Chazaud B.

In this study, Chazaud et al., evidenced that endothelial cells (ECs) and myogenic progenitor cells (MPCs) interacted to couple myogenesis and angiogenesis during skeletal muscle regeneration. EC- and MPC-derived Apelin, Oncostatin-M and Periostin controlled myogenesis/angiogenesis coupling and were required for myogenesis and vessel formation. Moreover, we showed that via the production of Oncostatin-M, restorative macrophages promoted myogenesis/angiogenesis coupling.


More information about the science of Bénédicte Chazaud

CNRS Press Release (french)

 

 
Delloye2018
Cancer Cell

Microenvironment-driven shift of a cohesion/scattering balance within tumors induces a switch towards metastasis in Neuroblastoma

Delloye-Bourgeois C, Bertin L, Thoinet K, Jarrosson L, Kindbeiter K, Buffet T, Tauszig-Delamasure S, Bozon M, Marabelle A, Combaret V, Bergeron C, Derrington E, Castellani V

The Castellani team developed an aggressive human neuroblastoma (NB) model based on the graft of NB cells at their primitive environment, the neural crest, in avian embryos. This model recapitulates both the primary tumor formation and NB cells secondary dissemination and allowed identifying two major routes of dissemination: peripheral nerves and aorta. The team described a microenvironment-induced pro-metastatic process, regulated by a cohesion signaling controlled by SEMA3C via NRP/PLXN complexes.


More information about the science of Valérie Castellani's team

 

 
Theret2017
EMBO Journal

AMPKα1-LDH pathway regulates muscle stem cell self-renewal by controlling metabolic homeostasis

Marine Theret, Linda Gsaier, Bethany Schaffer, Gaëtan Juban, Sabrina Ben Larbi, Michèle Weiss-Gayet, Laurent Bultot, Collodet Caterina, Marc Foretz, Dominique Desplanches, Pascual Sanz, Zizhao Zang, Lin Yang, Guillaume Vial, Benoit Viollet, Kei Sakamoto, Anne Brunet, Bénédicte Chazaud & Rémi Mounier

Theret et al. identify LDH as a new functional target of AMPKα1 in MuSCs, where it is a direct regulator by which the oxidative phosphorylation/aerobic glycolysis balance can be shifted to control differentiation/self-renewal.


More information about the science of Rémi Mounier and Bénédicte Chazaud's team

 
 

Research teams

INMG houses 14 research teams focusing on the physiology of the neuromuscular system, cellular and molecular neurobiology and nuclear dynamics.

News & Highlights

Jean-Louis Bessereau's team has launched the project "C.NAPSE" with the support of a prestigious ERC Advanced Grant (ERC AdG 2015) from the European Research Council.

The group of Jean-Louis Bessereau is investigating the molecular organization of chemical synapses, which are the specialized structures supporting communication between neurons in the brain and between neurons and muscles at neuromuscular junctions.

Seminars


Friday 29 June

Laure STROCHLIC

Institut de Myologie, Paris
Regulation of neuromuscular connectivity by Wnt signaling from signaling molecules to therapeutic strategies

Thursday 31 May

Robert J. Johnston

Johns Hopkins University, Baltimore
Stochastic gene expression and nuclear architecture in fly eyes and human retinal organoids


Job Offers

  • Team Chazaud Two post-doc positions in skeletal muscle stem cell environment [2018-01-08]
    Profile 1 – exploration of the role of extracellular matrix in skeletal muscle biology (PI: Dr. B Chazaud).
    Profile 2 – exploration of the role of myofiber contraction on skeletal muscle environment (PI: Dr. R Mounier).
    More info here
  • 2017-07-26 Julien Courchet's team is hiring a PhD STUDENT (3 years, ERC-funded) to study the molecular mechanisms involved in the local regulation of the energy metabolism in developing axon.
    More info here

Students & Training

L'INMG accueille et forme chaque année de nombreux étudiants à tous les niveaux de formation.

Facilities & Resources

Administration

Director
Pr. Laurent SCHAEFFER

Co-Director - Science policy
Pr. Jean-Louis BESSEREAU

Co-Directeur - Human resources
Dr. Guy MOUCHIROUD

Secretary General || Assistant to the Director
Andrée DEFOURS

Administrative hub et secretariat
Juliette CAMPANA
Laurence FOURNIER
Isabelle MEZZANO
Isabelle ROMERA
Jean-Sébastien GAILLARD

Research Teams

Students

L'INMG accueille et forme chaque année de nombreux étudiants à tous les niveaux de formation.
 
  • Internships
  • Graduate schools
    • BMIC - École Doctorale de Biologie Moléculaire, Intégrative et Cellulaire de Lyon
    • EDISS - École Doctorale Interdisciplinaire Sciences Santé
    • NSCo - Neurosciences et Cognition

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  • Assistant to the Director || Secretary general

    Andrée DEFOURS
    Tel.: +33 4 26 68 82 87
  • Institut NeuroMyoGène

    CNRS UMR 5310 - INSERM U1217 - Université Claude Bernard Lyon 1
    Faculté de Médecine et de Pharmacie - 3ème étage
    69008 Lyon
    France