INMG

Institut NeuroMyoGène


CNRS UMR 5310 - INSERM U1217 - Université de Lyon - Université Claude Bernard Lyon 1

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Découvrez le travail de Valérie Castellani, lauréate de la Médaille de l'Innovation du CNRS 2018.     Plus d'informations ici
L'INMG félicite Rémi Mounier, lauréat de la médaille de Bronze du CNRS 2018.     Plus d'informations ici

 
 
Innovation

Médaille de l'Innovation CNRS 2018

Valérie Castellani is a specialist in developmental biology at the INMG. Her career path, which includes founding the start-up Oncofactory, demonstrates the importance of basic research in the development of genuine groundbreaking innovation.
Valérie Castellani conducts basic research focused on understanding the cellular and molecular mechanisms that underpin the generation of neurons in the embryo, along with their migration and the arrangement of their neural connections via axon guidance. Her research led to the development of various experimental approaches, which she then transferred to the field of paediatric oncology. Her goal is to consider tumorigenesis and metastatic dissemination from the viewpoint of developmental biology, as well as the specific interactions of tumor cells with their immature microenvironment. Valérie Castellani developed a patented technology that has led to genuine progress in the field of personalised medicine. Her innovative technique makes it possible to faithfully reproduce—within the embryo of a bird—the evolution of a patient’s tumor cells, thereby enabling the search for new biomarkers, developing personalised medicine by predicting tumoral response, and experimenting with candidate medications. This patented innovation, which is both unexpected and unpredictable, is now being used by the start-up Oncofactory, jointly founded by Valérie Castellani and Céline Delloye-Bourgeois, a CNRS researcher at the Institut NeuroMyoGène.

CNRS press release
Cortex Mag Profile

 

 
Façade Rockefeller
GROUP LEADER POSITIONS IN LYON - 2018

The Institut NeuroMyoGène is opening junior and senior group leader positions

The INMG invites applications from outstanding candidates working in fields related to the INMG’s interests and motivated by innovative approaches. Candidates should have an excellent track record and meet the criteria to compete for national and international funding as well as for CNRS or Inserm research positions. Newly recruited group leaders will benefit from a stimulating research environment and comfortable laboratory space.

2018 INMG Call for junior and senior group leaders

 

 

We have moved!

2018new_lab

After two years of construction, the 200 members of the NeuroMyoGène Institute moved in late December 2017 into the beautifully renovated premises of the Rockefeller School of Medicine Lyon-Est.
This operation is part of the ambitious renovation project of the Rockefeller building built in 1929 by Paul Bellemain, student of Tony Garnier, and made possible by the support of the Auvergne Rhône-Alpes region, the métropole de Lyon, the Contrat Plan Etat Région and University Claude Bernard Lyon 1.
The 14 research teams of the institute occupy 3,500 m2 of lab and office space on the third floor of the building. They benefit from state-of-the-art technical platforms for imaging, physiology and genomics.
A 500 m2 extension of the laboratory will be completed at the end of 2018, and will allow a first wave of recruitment for new teams.


Invitation_INMG
 

 
 
Rare_disease_org
Talents CNRS

Médaille de Bronze – Lauréat INSB 2018

Rémi Mounier, chercheur en biologie au sein de l'équipe Environnement des cellules souches musculaires et homéostasie du muscle strié squelettique, est lauréat de la médaille de Bronze du CNRS 2018

La lecture du livre Autoportrait de l’auteur en coureur de fond par Haruki Murakami fut la confirmation de ce que je pensais du métier de chercheur. Dans ce roman, l’auteur japonais décrit comment la pratique de la course à pied lui permet de cultiver sa patience, sa presévérance et d’autres qualités requises pour un romancier, comme la ténacité et la capacité de concentration. En résumé, courir devient une métaphore de son travail d'écrivain. Le parralèle avec le travail d’un chercheur me semble pertinent. Dès lors, nous pouvons poursuivre l’exercice de style en mettant en avant d’autres qualités intrinsèques au métier de chercheur comme la nécessaire gestion de l'échec et la capacité à pratiquer cette activité individuelle de façon collective.

Télécharger son portrait ici 

 

 
UNC-120
Aging Cell

UNC-120/SRF independently controls muscle aging and lifespan in Caenorhabditis elegans.

Mergoud Dit Lamarche A, Molin L, Pierson L, Mariol MC, Bessereau JL, Gieseler K, Solari F

In this study, Mergoud et al. identify UNC-120/SRF as the first conserved transcription factor that regulates the pace of muscle aging in a cell autonomous manner, downstream of the insulin/IGF1 receptor.


More information about the science of Jean-Louis Bessereau's team

 

 
Chazaud2017
Stem Cell Reports

Coupling between Myogenesis and Angiogenesis during Skeletal Muscle Regeneration Is Stimulated by Restorative Macrophages

Latroche C, Weiss-Gayet M, Muller L, Gitiaux C, Leblanc P, Liot S, Ben-Larbi S, Abou-Khalil R, Verger N, Bardot P, Magnan M, Chrétien F, Mounier R, Germain S, Chazaud B.

In this study, Chazaud et al., evidenced that endothelial cells (ECs) and myogenic progenitor cells (MPCs) interacted to couple myogenesis and angiogenesis during skeletal muscle regeneration. EC- and MPC-derived Apelin, Oncostatin-M and Periostin controlled myogenesis/angiogenesis coupling and were required for myogenesis and vessel formation. Moreover, we showed that via the production of Oncostatin-M, restorative macrophages promoted myogenesis/angiogenesis coupling.


More information about the science of Bénédicte Chazaud

CNRS Press Release (french)

 

 
Delloye2018
Cancer Cell

Microenvironment-driven shift of a cohesion/scattering balance within tumors induces a switch towards metastasis in Neuroblastoma

Delloye-Bourgeois C, Bertin L, Thoinet K, Jarrosson L, Kindbeiter K, Buffet T, Tauszig-Delamasure S, Bozon M, Marabelle A, Combaret V, Bergeron C, Derrington E, Castellani V

The Castellani team developed an aggressive human neuroblastoma (NB) model based on the graft of NB cells at their primitive environment, the neural crest, in avian embryos. This model recapitulates both the primary tumor formation and NB cells secondary dissemination and allowed identifying two major routes of dissemination: peripheral nerves and aorta. The team described a microenvironment-induced pro-metastatic process, regulated by a cohesion signaling controlled by SEMA3C via NRP/PLXN complexes.


More information about the science of Valérie Castellani's team

 

 
Theret2017
EMBO Journal

AMPKα1-LDH pathway regulates muscle stem cell self-renewal by controlling metabolic homeostasis

Marine Theret, Linda Gsaier, Bethany Schaffer, Gaëtan Juban, Sabrina Ben Larbi, Michèle Weiss-Gayet, Laurent Bultot, Collodet Caterina, Marc Foretz, Dominique Desplanches, Pascual Sanz, Zizhao Zang, Lin Yang, Guillaume Vial, Benoit Viollet, Kei Sakamoto, Anne Brunet, Bénédicte Chazaud & Rémi Mounier

Theret et al. identify LDH as a new functional target of AMPKα1 in MuSCs, where it is a direct regulator by which the oxidative phosphorylation/aerobic glycolysis balance can be shifted to control differentiation/self-renewal.


More information about the science of Rémi Mounier and Bénédicte Chazaud's team

 
 

Research teams

INMG houses 14 research teams focusing on the physiology of the neuromuscular system, cellular and molecular neurobiology and nuclear dynamics.

News & Highlights

Laurent Schaeffer's team has been awarded funding by the Fondation pour la Recherche Médicale (FRM) through its "Espoirs de la recherche 2018" program.

The Schaeffer team develops a series of research topics dedicated to striated muscle and neuromuscular junction. The team also hosts clinicians that are involved in research projects aimed at developing innovative biomarkers and understanding the pathophysiology of neuromuscular disorders.

Seminars


Friday 30 November

Hugues NURY

Institut de Biologie Structurale, Grenoble
Structures and transitions of the serotonin 5-HT3 receptor

Friday 30 November

Emmanuel COMPE

Institut de Génétique et de Biologie Moléculaire et Cellulaire Illkirch, Strasbourg
TFIIH and TFIIE mutations: when transcriptional deficiencies lead to neurological disorders

Friday 14 December

Fabien LE GRAND

Centre de Recherche en Myologie, Paris
Signaling pathways in muscle tissue regeneration.

Friday 19 December

Bert Blaauw

Venetian Insitute of Molecular Medicine
The role of mTORC1 signaling in adult skeletal muscle.


Job Offers

  • Team Chazaud Two post-doc positions in skeletal muscle stem cell environment
    Profile 1 – exploration of the role of extracellular matrix in skeletal muscle biology (PI: Dr. B Chazaud).
    Profile 2 – exploration of the role of myofiber contraction on skeletal muscle environment (PI: Dr. R Mounier).
    More info here
  • Julien Courchet's team is hiring a PhD STUDENT (3 years, ERC-funded) to study the molecular mechanisms involved in the local regulation of the energy metabolism in developing axon.
    More info here

Students & Training

L'INMG accueille et forme chaque année de nombreux étudiants à tous les niveaux de formation.

Facilities & Resources

INMG teams have access to state-of-the-art facilities in house (SFR Santé Lyon Est). This includes a light and electron microscopy platform, a physiology/electrophysiology facility providing neuromuscular, cardiac and metabolic characterization of animal models, a genomic/transcriptomic platform, as well as mouse and zebrafish facilities.

In addition, the Université Claude Bernard Lyon 1 offers access to a broad spectrum of research equipements and facilites via its web portal Means.fr.

Administration

Director
Pr. Laurent SCHAEFFER

Co-Director - Science policy
Pr. Jean-Louis BESSEREAU

Co-Director - Human resources
Dr. Guy MOUCHIROUD

Secretary General || Assistant to the Director
Andrée DEFOURS

Administrative hub and secretariat
Juliette CAMPANA
Sahra FERKOUS
Laurence FOURNIER
Jean-Sébastien GAILLARD
Isabelle ROMERA

Research Teams

Students

L'INMG accueille et forme chaque année de nombreux étudiants à tous les niveaux de formation.
 
  • Internships
  • Graduate schools
    • BMIC - École Doctorale de Biologie Moléculaire, Intégrative et Cellulaire de Lyon
    • EDISS - École Doctorale Interdisciplinaire Sciences Santé
    • NSCo - Neurosciences et Cognition

logo_ucbl   logo_ucbl_hr   logo-cnrs   logo_inserm
  • Assistant to the Director || Secretary general

    Andrée DEFOURS
    Tel.: +33 4 26 68 82 87
  • Institut NeuroMyoGène

    CNRS UMR 5310 - INSERM U1217 - Université Claude Bernard Lyon 1
    Faculté de Médecine et de Pharmacie - 3ème étage
    69008 Lyon
    France