Publications in 2017

Coupling between Myogenesis and Angiogenesis during Skeletal Muscle Regeneration Is Stimulated by Restorative Macrophages.

Latroche C, Weiss-Gayet M, Muller L, Gitiaux C, Leblanc P, Liot S, Ben-Larbi S, Abou-Khalil R, Verger N, Bardot P, Magnan M, Chrétien F, Mounier R, Germain S, Chazaud B.

Stem Cell Reports 2017 Nov 24. pii: S2213-6711(17)30482-4.


More information about Bénédicte Chazaud’s team

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Myogenic Progenitor Cells Exhibit Type I Interferon-Driven Proangiogenic Properties and Molecular Signature During Juvenile Dermatomyositis.

Gitiaux C, Latroche C, Weiss-Gayet M, Rodero MP, Duffy D, Bader-Meunier B, Glorion C, Nusbaum P, Bodemer C, Mouchiroud G, Chelly J, Germain S, Desguerre I, Chazaud B.

Arthritis Rheumatol. 2017 Sep 21.


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High mobility group box 1 orchestrates tissue regeneration via CXCR4.

Tirone M, Tran NL, Ceriotti C, Gorzanelli A, Canepari M, Bottinelli R, Raucci A, Di Maggio S, Santiago C, Mellado M, Saclier M, François S, Careccia G, He M, De Marchis F, Conti V, Ben Larbi S, Cuvellier S, Casalgrandi M, Preti A, Chazaud B, Al-Abed Y, Messina G, Sitia G, Brunelli S, Bianchi ME, Vénéreau E.

J Exp Med. 2017 Dec 4. pii: jem.20160217.


More information about Bénédicte Chazaud’s team

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AMPK in skeletal muscle function and metabolism.

Kjøbsted R, Hingst JR, Fentz J, Foretz M, Sanz MN, Pehmøller C, Shum M, Marette A, Mounier R, Treebak JT, Wojtaszewski JFP, Viollet B, Lantier L.

FASEB J. 2017 Dec 14. pii: fj.201700442R.


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The Clinical Use of Neuromuscular Electrical Stimulation for Neuromuscular Rehabilitation: What Are We Overlooking?

Maffiuletti NA, Gondin J, Place N, Stevens-Lapsley J, Vivodtzev I, Minetto MA.

Arch Phys Med Rehabil. 2017 Dec 9. pii: S0003-9993(17)31395-3


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Biallelic mutation of UNC50, encoding a protein involved in AChR trafficking, is responsible for arthrogryposis.

Abiusi E, D’Alessandro M, Dieterich K, Quevarec L, Turczynski S, Valfort AC, Mezin P, Jouk PS, Gut M, Gut I, Bessereau JL, Melki J.

Hum Mol Genet. 2017 Oct 15;26(20):3989-3994


More information about Jean-Louis Bessereau’s team

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Regulation of Akt-mTOR, ubiquitin-proteasome and autophagy-lysosome pathways in locomotor and respiratory muscles during experimental sepsis in mice.

Morel J, Palao JC, Castells J, Desgeorges M, Busso T, Molliex S, Jahnke V, Del Carmine P, Gondin J, Arnould D, Durieux AC, Freyssenet D.

Sci Rep. 2017 Sep 7;7(1):10866.


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Specific brain activation patterns associated with two neuromuscular electrical stimulation protocols.

Wegrzyk J, Ranjeva JP, Fouré A, Kavounoudias A, Vilmen C, Mattei JP, Guye M, Maffiuletti NA, Place N, Bendahan D, Gondin J.

Sci Rep. 2017 Jun 2;7(1):2742.


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Methodological considerations for investigating the influence of neuromuscular electrical stimulation on pH heterogeneity.

Jubeau M, Gondin J.

Magn Reson Med 2017 Feb;77(2):465.


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Theret2017

EMBO Journal

AMPKα1-LDH pathway regulates muscle stem cell self-renewal by controlling metabolic homeostasis.

Marine Theret, Linda Gsaier, Bethany Schaffer, Gaëtan Juban, Sabrina Ben Larbi, Michèle Weiss-Gayet, Laurent Bultot, Collodet Caterina, Marc Foretz, Dominique Desplanches, Pascual Sanz, Zizhao Zang, Lin Yang, Guillaume Vial, Benoit Viollet, Kei Sakamoto, Anne Brunet, Bénédicte Chazaud & Rémi Mounier

Theret et al. identify LDH as a new functional target of AMPKa1 in MuSCs, where it is a direct regulator by which the oxidative phosphorylation/aerobic glycolysis balance can be shifted to control differentiation/self-renewal.


Plus d’informations sur l’équipe de Rémi Mounier et Bénédicte Chazaud

Pubmed 


Angelov2017

Molecular Cell

Structure and Dynamics of a 197 bp Nucleosome in Complex with Linker Histone H1

Bednar J, Garcia-Saez I, Boopathi R, Cutter AR, Papai G, Reymer A, Syed SH, Lone IN, Tonchev O, Crucifix C, Menoni H, Papin C, Skoufias DA, Kurumizaka H, Lavery R, Hamiche A*, Hayes JJ*, Schultz P*, Angelov D*, Petosa C*, Dimitrov S*

Cryo-EM and crystal structures of the nucleosome bound to histone H1 were determined. H1 binding induces the nucleosome to adopt a more compact and rigid conformation. The H1 globular domain interacts with core DNA on the dyad and with both DNA linkers. The H1 C-terminal domain associates primarily with a single DNA linker.

Pubmed 


do2017

Neurology

Characteristics in limbic encephalitis with anti–adenylate kinase 5 autoantibodies.

Do LD, Chanson E, Desestret V, Joubert B, Ducray F, Brugière S, Couté Y, Formaglio M, Rogemond V, Thomas-Antérion C, Borrega L, Laurens B, Tison F, Curot J, De Brouker T, Lebrun-Frenay C, Delattre JY, Antoine JC, Honnorat J.

Limbic encephalitis (LE) is a temporal lobe inflammatory disorder characterized by seizures, short-term memory deficits, and behavioral disturbances. By using immunoprecipitation and mass spectrometry, we identified autoantibodies anti-Adenylate kinase 5 (AK5-Abs) as specific marker in 10 patients with LE. We described here the biological and clinical characteristics of this group of patients.


More information about the science of Jérôme Honnorat’s team

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Molecular Memory of Morphologies by Septins during Neuron Generation Allows Early Polarity Inheritance.

Boubakar L, Falk J, Ducuing H, Thoinet K, Reynaud F, Derrington E, Castellani V.

Neuron 2017 Aug 16;95(4):834-851.e5.


More information about Valérie Castellani’s team

Pubmed 


Cryptic amyloidogenic elements in mutant NEFH causing Charcot-Marie-Tooth 2 trigger aggresome formation and neuronal death.

Jacquier A, Delorme C, Belotti E, Juntas-Morales R, Solé G, Dubourg O, Giroux M, Maurage CA, Castellani V, Rebelo A, Abrams A, Züchner S, Stojkovic T, Schaeffer L, Latour P.

Acta Neuropathol Commun. 2017 Jul 14;5(1):55.


More information about Valérie Castellani’s team

Pubmed 


Resistance exercise initiates mechanistic target of rapamycin (mTOR) translocation and protein complex co-localisation in human skeletal muscle.

Song Z, Moore DR, Hodson N, Ward C, Dent JR, O’Leary MF, Shaw AM, Hamilton DL, Sarkar S, Gangloff YG, Hornberger TA, Spriet LL, Heigenhauser GJ, Philp A.

Sci Rep. 2017 Jul 10;7(1):5028.


More information about Laurent Schaeffer’s team

Pubmed 


Genetic specification of left-right asymmetry in the diaphragm muscles and their motor innervation.

Charoy C, Dinvaut S, Chaix Y, Morlé L, Sanyas I, Bozon M, Kindbeiter K, Durand B, Skidmore JM, De Groef L, Seki M, Moons L, Ruhrberg C, Martin JF, Martin DM, Falk J, Castellani V.

Elife 2017 Jun 22;6. pii: e18481.


More information about Valérie Castellani’s team

Pubmed 


Nerve Growth Factor Signaling from Membrane Microdomains to the Nucleus: Differential Regulation by Caveolins.

Spencer A, Yu L, Guili V, Reynaud F, Ding Y, Ma J, Jullien J, Koubi D, Gauthier E, Cluet D, Falk J, Castellani V, Yuan C, Rudkin BB.

Int J Mol Sci. 2017 Mar 24;18(4). pii: E693.


More information about Valérie Castellani’s team

Pubmed 


Performing Axon Orientation Assays with Secreted Semaphorins and Other Guidance Cues.

Delloye-Bourgeois C, Moret F, Castellani V.

Methods Mol Biol. 2017 1493:237-246.


More information about Valérie Castellani’s team

Pubmed 


PPARγ transcription factor controls in anti-inflammatory macrophages the expression of GDF3 that stimulates myogenic cell fusion during skeletal muscle regeneration.

Mounier R, Chazaud B.

Med Sci (Paris). 2017 May;33(5):466-469


More information about Bénédicte Chazaud’s team

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Metabolic regulation of macrophages during tissue repair: insights from skeletal muscle regeneration.

Juban G, Chazaud B.

FEBS Lett. 2017 May 29. doi: 10.1002/1873-3468.12703.


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Human skeletal muscle fibroblasts stimulate in vitro myogenesis and in vivo muscle regeneration.

Mackey AL, Magnan M, Chazaud B, Kjaer M

Journal of Physiology 2017 Mar 30. doi: 10.1113/JP273997.


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Reliable CRISPR/Cas9 Genome Engineering in Caenorhabditis elegans Using a Single Efficient sgRNA and an Easily Recognizable Phenotype.

El Mouridi S, Lecroisey C, Tardy P, Mercier M, Leclercq-Blondel A, Zariohi N, Boulin T

G3 Genes|Genomes|Genetics 2017 Mar 9. pii: g3.117.040824. doi: 10.1534/g3.117.040824.


More information about Thomas Boulin’s team

Pubmed 


Effects of Macrophage Conditioned-Medium on Murine and Human Muscle Cells: Analysis of Proliferation, Differentiation, and Fusion.

Saclier M, Theret M, Mounier R, Chazaud B

Methods Mol Biol. 2017 1556:317-327


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LSD1 Controls Timely MyoD Expression via MyoD Core Enhancer Transcription.

Scionti I, Hayashi S, Mouradian S, Girard E, Esteves de Lima J, Morel V, Simonet T, Wurmser M, Maire P, Ancelin K, Metzger E, Schüle R, Goillot E, Relaix F, Schaeffer L

Cell Reports 2017 Feb 21;18(8):1996-2006. doi: 10.1016/j.celrep.2017.01.078.


More information about Laurent Schaeffer’s team

Pubmed 


Redox Control of Skeletal Muscle Regeneration.

Le Moal E, Pialoux V, Juban G, Groussard C, Zouhal H, Chazaud B, Mounier R.

Antioxid Redox Signal 2017 Feb 6. doi: 10.1089/ars.2016.6782.


More information about Rémi Mounier’s team

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