A critical role for VEGF and VEGFR2 in NMDA receptor synaptic function and fear-related behavior.
De Rossi P, Harde E, Dupuis JP, Martin L, Chounlamountri N, Bardin M, Watrin C, Benetollo C, Pernet-Gallay K, Luhmann HJ, Honnorat J, Malleret G, Groc L, Acker-Palmer A, Salin PA, Meissirel C.
Increasing evidence indicate that the vascular endothelial growth factor (VEGF) can facilitate memory performances but its impact on synapses remains poorly understood. De Rossi et al. now show that VEGF exerts a direct effect on synapse structure and function through its receptor VEGFR2 on neurons. This VEGF-VEGFR2 pathway is required for hippocampal synaptic plasticity and consolidation of memory.
Phosphatidylinositol 3-kinase inhibition restores Ca2+ release defects and prolongs survival in myotubularin-deficient mice
Candice Kutchukian, Mirella Lo Scrudato, Yves Tourneur, Karine Poulard, Alban Vignaud, Christine Berthier, Bruno Allard, Michael W. Lawlor, Ana Buj-Bello, and Vincent Jacquemond
Myotubular myopathy is a fatal disease resulting from deficiency in the phosphoinositide phosphatase MTM1. Kutchukian et al. (2016) have now identified critical pathophysiological alterations of Ca2+ signaling which are involved in the disease and have revealed the benefit of a pharmacological treatment.
The Flexible Ends of CENP-A Nucleosome Are Required for Mitotic Fidelity.
Roulland Y, Ouararhni K, Naidenov M, Ramos L, Shuaib M, Syed SH, Lone IN, Boopathi R, Fontaine E, Papai G, Tachiwana H, Gautier T, Skoufias D, Padmanabhan K, Bednar J, Kurumizaka H, Schultz P, *Angelov D, *Hamiche A, *Dimitrov S.
CENP-A nucleosomal ends are highly flexible in solution, which prevents recruitment of the linker histone H1 thus allowing assembly of active kinetochore complex. Open CENP-A nucleosomal structure is essential for its mitotic function.
Macrophage PPARgamma, a Lipid Activated Transcription Factor Controls the Growth Factor GDF3 and Skeletal Muscle Regeneration.
Tamas Varga, Rémi Mounier, Andreas Patsalos, Péter Gogolák, Matthew Peloquin, Attila Horvath, Attila Pap, Bence Daniel, Gergely Nagy, Eva Pintye, Szilárd Poliska, Sylvain Cuvellier, Sabrina Ben Larbi, Brian E. Sansbury, Matthew Spite, Chester W. Brown, Bénédicte Chazaud, Laszlo Nagy
PPARγ is a lipid activated transcription factor essential for fat cells and linked to lipid processing in macrophages. Varga et al. (2016) now show that PPARγ is transcriptionally active and regulates the growth factor Gdf3 in repair macrophages in regenerating skeletal muscle, forming a paracrine axis connecting macrophages to muscle progenitor fusion.
Chromatin associated mechanisms in base excision repair – nucleosome remodeling and DNA transcription, two key players.
Menoni H, Di Mascio P, Cadet J, Dimitrov S, Angelov D.
Evidence for ARGONAUTE4-DNA interactions in RNA-directed DNA methylation in plants.
Lahmy S, Pontier D, Bies-Etheve N, Laudié M, Feng S, Jobet E, Hale CJ, Cooke R, Hakimi MA, Angelov D, Jacobsen SE, Lagrange T.
Real-Time Tracking of Parental Histones Reveals Their Contribution to Chromatin Integrity Following DNA Damage.
Salomé Adam, Juliette Dabin, Odile Chevallier, Olivier Leroy, Céline Baldeyron, Armelle Corpet, Patrick Lomonte, Olivier Renaud, Geneviève Almouzni, and Sophie E. Polo
Characterization of a Subtype of Autoimmune Encephalitis With Anti-Contactin-Associated Protein-like 2 Antibodies in the Cerebrospinal Fluid, Prominent Limbic Symptoms, and Seizures.
Joubert B, Saint-Martin M, Noraz N, Picard G, Rogemond V, Ducray F, Desestret V, Psimaras D, Delattre JY, Antoine JC, Honnorat J.
Journal of Cell Biology
Transition zone assembly and its contribution to axoneme formation in Drosophila male germ cells
Jennifer Vieillard, Marie Paschaki, Jean-Luc Duteyrat, Céline Augière, Elisabeth Cortier, Jean-André Lapart, Joëlle Thomas, Bénédicte Durand
Ciliary transition zone (TZ) assembly is complex and incompletely understood. Vieillard et al. show that Drosophila Cby and Dila cooperate to assemble the TZ and membrane cap, which, together with microtubule remodeling by kinesin-13, is required for axoneme formation in male germ cells.