A CRITICAL ROLE FOR VEGF AND VEGFR2 IN NMDA RECEPTOR SYNAPTIC FUNCTION AND FEAR-RELATED BEHAVIOR.
De Rossi P, Harde E, Dupuis JP, Martin L, Chounlamountri N, Bardin M, Watrin C, Benetollo C, Pernet-Gallay K, Luhmann HJ, Honnorat J, Malleret G, Groc L, Acker-Palmer A, Salin PA, Meissirel C.
Increasing evidence indicate that the vascular endothelial growth factor (VEGF) can facilitate memory performances but its impact on synapses remains poorly understood. De Rossi et al. now show that VEGF exerts a direct effect on synapse structure and function through its receptor VEGFR2 on neurons. This VEGF-VEGFR2 pathway is required for hippocampal synaptic plasticity and consolidation of memory.