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RESEARCH ASSISTANTS AND TECHNICIANS

• Team Honnorat – One research engineer/biologist position

We are looking for an assistant engineer (AI), to perform surgery on rodents. The candidate must have at least a level two in animal experimentation and a training in surgery.
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POST-DOCTORAL RESEARCHERS, RESEARCH SCIENTISTS

• Équipe Le Grand – Post-doc

The team of Fabien Le Grand at the Institute NeuroMyoGène in Lyon is looking for a Postdoc fellow in Experimental Single-Cell Biology for an initial period of two years. We are studying signaling pathways in adult muscle cells, their impact on tissue regeneration and how different signals are integrated to control stem cell fate.

Aim of this project is to use single-cell assays to provide an unbiased elucidation of the cellular events underlying the different steps of muscle disease progression. The fellow will use the mouse models of muscular pathologies and perform droplet-based single-cell RNA-seq as well as spatial transcriptomics. She/he will be expected to perform computational analysis of the data with available methods.

Candidate should have a PhD in Life Science and a strong knowledge in basic Molecular Biology techniques. Background in single-cell omics is a strong plus. Background in muscle pathophysiology studies is also a plus. At least one first author paper in an international peer-reviewed journal.

We are looking for a motivated team player with strong communication skills and the desire to work in a dynamic laboratory. We provide a challenging environment with the freedom to follow your instinct and be creative. Lyon, with its numerous lakes and its vicinity to the Alps, is considered to be one of the cities with the best quality of life in France. With its first-class universities and research institutes it offers an intellectually stimulating environment.

Remuneration and social benefits are based on the CNRS agreement for public-sector employees. The position is (initially) for 2 years, but an extension can be arranged. The objective is to apply for long-term post-doctoral fundings with “Fondation de France”, ANR JCJC, “Association Française contre les Myopathies” etc.

Elements to be provided: application should include a CV, a cover letter and a recommendation letter to Fabien.le-grand@inserm.fr

Recent publication from the team

1: Parisi A et al. APC is required for muscle stem cell proliferation and skeletal muscle tissue repair. The Journal of Cell Biology. 2015 Aug 31;210(5):717-26.

2: Rudolf A, et al. β-Catenin Activation in Muscle Progenitor Cells Regulates Tissue Repair. Cell Reports. 2016 May 10;15(6):1277-90.

3: Lacour F, et al. R-spondin1 Controls Muscle Cell Fusion through Dual Regulation of Antagonistic Wnt Signaling Pathways. Cell Reports. 2017 Mar 7;18(10):2320-2330.

4: Giordani L et al. High-Dimensional Single-Cell Cartography Reveals Novel Skeletal Muscle-Resident Cell Populations. Molecular Cell. 2019 May 2;74(3):609-621.e6.