INMG

The Institut NeuroMyoGène (INMG) is a novel institute dedicated to the study of the nervous and muscular systems. It was created in 2016 in Lyon at the heart of a dense hospital network and of one of the biggest medical universities in France.

The INMG goal is to unravel fundamental aspects of the cell biology of the muscle and nervous system from development to aging under normal and pathological conditions. Using a variety of invertebrate and vertebrate model systems, the INMG is conducting an integrated multidisciplinary research from gene to physiological functions. One of its priorities is to develop relevant strategies to decipher multiple forms of neuromuscular diseases, identify new therapeutic targets and foster novel strategies for innovative treatments. The INMG benefits from the integration of cutting-edge fundamental research teams and renowned clinicians, including the directors of three reference centers for neuromuscular diseases, paraneoplastic syndromes and genetic cardiac rhythm diseases.

The INMG is a consortium of three research organizations : the CNRS, the INSERM and the University Claude Bernard in Lyon. The Institute also gets strong support from the French Association against Myopathies (AFM). It gathers 14 individual research teams and about 190 people. In January 2018, the fourteen INMG teams have moved into newly renovated laboratory and office space on the Rockefeller Medical school campus. Within the next years the Institute will be able to host up to 250 people, with a total of 5000 m2 lab and office space.


PRESENTATION

Neuromuscular diseases represent more than 150 genetic and acquired disorders, many of which cause progressive muscle wasting and premature death. The NeuroMyoGene Institute (INMG) is a new institute dedicated to the study of the nervous and muscular systems. It was created in January 2016 in Lyon in the heart of a dense hospital network and one of the largest faculties of medicine in France.

The neuromuscular system is in essence an integrated system in which neuromuscular junctions, prototypical chemical synapses, convey bidirectional signaling necessary for structuring and maintaining muscles and motoneurons. The INMG brings together a community of researchers and clinicians with expertise at all levels of the neuromuscular system (neurons, neuromuscular junction, muscles, immune cells, vascular cells …) and developing multidimensional approaches ranging from molecular biology, cell biology and electrophysiology to integrated human physiology.

The INMG is supported by three supervisory bodies : the University Claude Bernard Lyon 1, CNRS and INSERM. The Institute also enjoys strong support from the French Association against Myopathies (AFM-Telethon) through the MyoNeurALP strategic alliance. The INMG is the result of the gathering of 8 Lyon research teams working on cellular neurobiology and the neuromuscular system, and the arrival of 6 new research teams from Paris, Toulouse, Melbourne and New York. It brings together 14 individual research teams and about 200 people. In the coming years, the Institute will be able to accommodate up to 350 people.

The INMG has four main priorities :

– Develop high level fundamental research in molecular and cellular biology, genetics and physiology in an environment that promotes the application of discoveries to human pathologies

– Develop translational research projects, particularly in the area of ​​neuromuscular diseases.

– Promote collaborations for the establishment of advanced technology platforms and joint research programs with academic and industrial research

– Renew and develop the training offer for students in scientific and medical disciplines.

Over the last five years, INMG teams have published 450 articles in international peer-reviewed journals. The average impact factor (IF) for the INMG groups was greater than 6 and about 50 articles were published in journals with an IF> 10. In addition, INMG members participate in more than 150 national projects and four ERC grants and two EU collaborative networks (more than € 34 million in external funding).


THE DIRECTOR’S WORD

Dear visitor,

Welcome at the INMG.

Since 2018 we are located in the splendid renovated premises of the so called “Rockefeller” faculty of medicine and pharmacy of Lyon. This emblematic building of Lyon university, inspired by Tony Garnier, was built in 1929 following a European call for proposals launched by the Rockefeller foundation to create a place of teaching and research where students, researchers and medical doctors could, and would, interact. The installation of the INMG in this building is perfectly in line with this logic and provides renewed momentum to the original spirit that presided at its construction almost one century ago.

INMG is a laboratory of Claude Bernard university, affiliated to CNRS and INSERM. It gathers a community of researchers, engineers, technicians and medical doctors to develop cutting edge fundamental and biomedical research on the nervous and neuromuscular system.

Our goal is to better understand the mechanisms that control the formation, function and maintenance of the nervous and neuromuscular system. Our fundamental research provides a strong basis on which we build a better understanding of neurological and neuromuscular disorders, and develop new therapeutic strategies and innovative diagnostics for patients.

High quality biomedical research requires the basis of an excellent fundamental research. It also requires a great proximity with the medical environment. INMG implantation in the faculty of medicine and pharmacy, at the heart of the largest hospital campus of Lyon, is a precious asset for our ability to translate the research results of our teams into clinical applications.

Our teams actively participate to develop cutting edge technological platforms, giving us access to state-of-the-art microscopy, physiology and electrophysiology, histology and next generation sequencing platforms. We are one of the rare places able to provide comprehensive characterization of skeletal muscle function, including force production, neurotransmission, excitation/contraction coupling, metabolism and histology. Such skills are precious to characterize preclinical models and evaluate therapeutic molecules.

Our valorization strategy also includes strong and long lasting links with companies. Laboratory space is available to develop collaborative projects with private companies or host start-ups. We also encourage entrepreneurship through the creation of spin-off companies, such as Oncofactory that we currently host.

Academic or industry scientist, student, patient, patient’s family or simply curious visitor, along the pages of our web site you will find more details about the various activities of our institute.

I wish you a pleasant visit,

Professor Laurent Schaeffer

INMG director


THE THEMES

Using a variety of model systems, the INMG conducts integrated multidisciplinary research ranging from gene to physiological functions to understand the development and function of muscles and the nervous system in the course of life from embryonic development until aging.

The main research themes of the INMG are:

  • Neuronal and muscular development
  • Biology of the synapse
  • Stability and maintenance of the genome in postmitotic cells
  • Cell processes involved in normal and pathological muscle aging
  • Cellular excitability: from ion channels to integrated cell physiology
  • Regeneration mechanisms and their relevance for muscular pathologies
  • Improved diagnosis and treatment of patients

The INMG brings together:

  • Skills at all levels of the neuromuscular system (motor neurons, muscle fibers, neuromuscular junction, muscle precursor cells), genetic approaches, molecular and cellular biology, physiology and electrophysiology
  • The highest concentration of French teams studying the expression of muscle genes, muscle precursors, neuromuscular junction, excitability and excitation-contraction coupling of muscle cells
  • Internationally-oriented teams that develop powerful models for the study of the neuromuscular system and the nervous system.

INMG has recognized biomedical expertise:

  • Cell biology, biochemistry and genetics for the diagnosis of myopathies and cardiomyopathies
  • Functional studies of the neuromuscular junction as well as studies on excitation-contraction coupling
  • Inflammatory diseases of muscles and nervous system

CONTACTS
  • Andrée Defours : Secrétaire générale. RESPONSABILITES
  • Karine Langou : Chargée de mission. RESPONSABILITES

USEFUL INFORMATION
  • Laboratory access
  • Lab map

ORGANIZATIONAL CHART OF THE INSTITUTE