The team develops a series of research topics dedicated to striated muscle and neuromuscular junction. The initial work was mainly focused on the study of the regulation of muscle chromatin and gene expression by motor innervation. Our results progressively led us to explore additional fields of muscle biology such as PI3K/mTOR intracellular trafficking and signalling, actin cytoskeleton, energy metabolism, and protein degradation.
Some discoveries and techniques developed by the team have direct implications for the diagnostic or the treatment of neuromuscular disorders. The team hosts clinicians that are involved in research projects aimed at developing innovative biomarkers and understanding the pathophysiology of neuromuscular disorders.
The team develops 3 fundamental research themes and 2 translational research themes:
2005-2015 MAJOR SCIENTIFIC ACHIEVEMENTS
REGULATION OF MUSCLE GENE EXPRESSION BY MOTOR INNERVATION
NEUROMUSCULAR JUNCTION AND NUCLEI POSITIONING
Nesprins control nuclei position and postsynaptic receptors density in skeletal muscle (Morel et al. 2014).
DECIPHERING THE ROLE OF PI3K/MTOR SIGNALLING IN SKELETAL MUSCLE
Faculté de Médecine
3ème étage, Aile B
8 Avenue Rockefeller