INMG offers a dynamic and international environment for research training, and welcomes a variety of students.
MASTER STUDENTS INTERNSHIPS
- Team Lomonte – NEW OFFER : M2 year 2021-2022
3D imaging of latent HSV-1 and KSHV genomes by super-resolution microscopy
Herpesviruses persist in the nucleus of the host cell for the life of the infected individual. They persist as a minichromosome which is not integrated into the cell genome. In the case of herpes simplex virus type 1 (HSV-1), this minichromosome is contained in cellular structures, called promyelocytic leukemia nuclear bodies or PML NBs. In the case of Kaposi’s sarcoma associated virus (KSHV), the viral genome is bound by the viral protein LANA. Information on the three-dimensional structure of these viral genomes in the nucleus of the host cell remains incomplete. The study of these structures by super-resolution imaging will allow a better understanding of these viruses.
The student will be in charge of preparing infected cells, labeling them and acquiring, reconstructing and analyzing dSTORM and STED-3D super-resolution images.
- Équipe Bessereau – M2
Genetic control of acetylcholine receptor biosynthesis: from C. elegans to human pathologies.
Dysfunction of acetylcholine receptors is linked to several pathologies, including myasthenia or schizophrenia. The quantity of the receptors at the plasma membrane is thus finely tuned and results from a balance between biosynthesis, recycling and degradation of the receptors. The aim of the internship is to characterize the role of two proteins, TMED7 and TMED2, in the biogenesis of the receptors.