We investigate the role of environmental signals during the physiological and pathological wiring of the nervous system.
neuronal development cell polarity axon guidance cell division cell migration cancer
Polarization, which confers asymmetry at molecular, cellular and tissue scales, is a fundamental process establishing key features of biological systems. In multicellular organisms, symmetry breaking triggers the specification of embryonic body axes, providing general landmarks for subsequent morphogenetic programs. Cells and tissues acquire complex morphological and functional polarity features, which, remarkably, are highly precisely positioned within the general body landmarks. The lab is interested in understanding the mechanisms setting the spatial orientation of some selected polarity processes, taking place during the formation of the nervous system. We investigate the topography of progenitor cell divisions, and neuronal differentiation, using the developing spinal cord and sensorimotor circuits as a model. We also investigate how topographic cues impact on a closely related pathological context, the neuroblastoma, a neuro-developmental cancer arising from trunk neural cell crest. We exploit chick and mouse embryo animal models, combined with live imaging, cell and tissue cultures and molecular approaches.
OncoFactory is a start-up founded in 2016 as a spin-off of the Castellani lab, based on the work of Dr. Céline Delloye Bourgeois and Dr. Valérie Castellani at the NeuroMyoGene Institute in Lyon. OncoFactory offers an innovative in vivo model suited for all cancers consisting in the creation of miniaturized replicas of patient tumors in an embryonic organism. Tumors are analyzed in the whole organism using 3D imaging. Replicas can be collected back for a range of molecular analysis. Using this innovative technological platform OncoFactory evaluates the efficacy and studies the mechanisms of action of therapeutic candidates, help the design of combi-therapies through a dedicated program integrating analysis of tumor responses to the candidate therapy and characterization of candidate therapy-induced activated signaling pathways, identifies biomarkers/gene signatures to predict the response and the resistance. https://www.oncofactory.com/
UCBL – CNRS UMR 5310 – INSERM U1217
Faculté de Médecine et de Pharmacie – 3ème étage – Couloir A
8 Avenue Rockefeller