We investigate the role of environmental signals during the physiological and pathological wiring of the nervous system.
neuronal development cell polarity axon guidance cell division cell migration cancer
Polarization, which confers asymmetry at molecular, cellular and tissue scales, is a fundamental process establishing key features of biological systems. In multicellular organisms, symmetry breaking triggers the specification of embryonic body axes, providing general landmarks for subsequent morphogenetic programs. Cells and tissues acquire complex morphological and functional polarity features, which, remarkably, are highly precisely positioned within the general body landmarks. The lab is interested in understanding the mechanisms setting the spatial orientation of some selected polarity processes, taking place during the formation of the nervous system. We investigate the topography of progenitor cell divisions, and neuronal differentiation, using the developing spinal cord and sensorimotor circuits as a model. We also investigate how topographic cues impact on a closely related pathological context, the neuroblastoma, a neuro-developmental cancer arising from trunk neural cell crest. We exploit chick and mouse embryo animal models, combined with live imaging, cell and tissue cultures and molecular approaches.
« Oncofactory is a spin-off of the Castellani lab that adapted the avian tumoral model to patients samples of many adult cancers. Oncofactory proposes this novel patient derived tumoral models for preclinical testing of therapy efficacy. This avian model is used in preclinical programs of pharma industry and is also proposed for the identification of biomarkers predictive of the patient response. »
UCBL – CNRS UMR 5310 – INSERM U1217
Faculté de Médecine et de Pharmacie – 3ème étage – Couloir A
8 Avenue Rockefeller